• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
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    • 专利摘要:
    A valve assembly (100) for reducing the migration of one or more viruses through a filter (110), when the inflow stream to the filter (110) is resumed after a reduction in the inflow stream, includes an inlet conduit (102) having an inlet port (104), which is to be connected to a product supply (127) and an outlet port (108) to be connected to an inlet (109) of the filter (110), a pump (124), an outlet conduit (112) and a recirculation system (132 ). The recirculation system (132) includes a recirculation line (130) connecting the outlet line (112) and the inlet line (102) and a check valve (122) disposed along the recirculation line (130). When the check valve (122) detects the reduction in the inflow, a recirculation loop is established so that the product (126) is continually returned through the filter (110) during the reduction, whereby a continuous flow of fluid through the filter (110) also during the Reduction is guaranteed.
    公开号:CH714987A2
    申请号:CH5632019
    申请日:2019-04-29
    公开日:2019-11-15
    发明作者:D Brandt Michael
    申请人:Asahi Kasei Bioprocess America Inc；
    IPC主号:
    专利说明:

    description
    TECHNICAL FIELD OF THE INVENTION The present disclosure relates generally to virus filter systems and, more particularly, to a system and method for ensuring continuous flow through a virus removal filter to prevent virus migration through the virus removal filter after a reduction in inflow.
    BACKGROUND ART Pharmaceutical drugs that are made, extracted, or synthesized from biological sources must undergo virus reduction steps to reduce the potential for viral contamination in the drug itself. Blood products and derivatives must also go through virus reduction steps to reduce the potential for viral contamination in the product. One of these known methods of virus reduction is size exclusion filtering. By using size exclusion filtering, an inflow containing the product to be filtered is passed through a virus removal filter. The virus removal filter has a virus filtration membrane that collects the viruses to be removed from the product. To capture the virus, the membrane is made to have millions of cavities that connect to multiple capillaries, which in turn connect to a grid through which the liquid must pass to exit the filter. Therefore, a virus entrained in the fluid stream has a tortuous path to find a way through the virus filter membrane to exit. In this tortuous or tortuous path, a size exclusion virus can be trapped in or around a capillary. It can also be held in such a cavity by flow forces or affinity for a cavity wall. For example, to capture a virus with a cross-sectional diameter of 17 nanometers (»nm»), the capillaries must have a cross-sectional diameter of less than 17 nm anywhere along their length, or a cavity must have a virus with a cross-sectional diameter of less than 17 nanometers due to flow forces or affinity hold back to the walls of the cavity.
    A reduction in the inflow through the virus removal filter can occur during the filtration process for various reasons. For example, a reduction in the inflow through the virus removal filter can occur as a result of a reduction in the supply and inflow of the filter. Alternatively or additionally, a reduction in the inflow or inflow through the virus removal filter may occur as a result of valve switching, valve failure, pneumatic failure, mechanical failure, electrical failure and other intentional or unintentional actions or events. In any case, such a reduction in the inflow reduces the flow through the virus removal filter or even discontinuously.
    However, a virus retained by fluid flow or affinity for the walls of a cavity can find its way out of the retention medium through Brownian motion if the fluid flow through the cavity is reduced (either partially or completely). In other words, during the reduced inflow flow, a virus can move around a cavity through Brownian motion. Brownian motion can move a virus far enough away from where it was held in the cavity, so that when full inflow through the cavity is resumed, a virus is carried into the flow and the cavity into a capillary or leaves another cavity. If a virus is carried into the flow of the flow and emerges from a cavity once it has been retained by that cavity, it has another chance of migrating through the virus filtration membrane, which undesirably increases the chances of the virus completely passing through the virus removal filter elevated.
    A reduced or discontinuous inflow flow through a virus removal filter during the filtration process thus leads to a higher probability that a virus will migrate through the virus removal filter when the full inflow flow is resumed. In other words, reducing the inflow flow through a virus removal filter during the filtration process increases the likelihood that a virus will find its way through the virus removal filter when the full inflow flow is resumed. It should therefore be noted that reducing the inflow with a virus removal filter during the filtration process is a problem.
    BRIEF DESCRIPTION OF THE DRAWINGS The features of the present disclosure that are considered novel are set forth particularly in the appended claims. The present disclosure can best be understood with reference to the following description in conjunction with the accompanying drawings, in which like reference numerals designate like elements in the individual figures, in which:
    1 is a schematic illustration of an example of a valve assembly constructed in accordance with the teachings of the present disclosure to reduce the migration of one or more viruses across a virus removal membrane when the full flow is resumed after the flow has been reduced;
    CH 714 987 A2
    FIG. 2 is a schematic illustration of another example of a valve assembly constructed in accordance with the teachings of the present disclosure to reduce migration of one or more viruses across a virus removal membrane when the full supply is resumed after the supply has been reduced;
    3 is a schematic illustration of another example of a valve assembly constructed in accordance with the teachings of the present disclosure to reduce migration of one or more viruses across a virus removal membrane when full flow is resumed after the flow has been reduced.
    DETAILED DESCRIPTION The present disclosure is generally directed to a valve assembly to reduce migration of one or more viruses through a virus removal filter when the inflow flow is resumed after the inflow flow through the virus removal filter has been reduced. The valve arrangement disclosed herein reduces migration of one or more viruses by ensuring that a continuous fluid flow is provided through the virus removal filter in the event of a decrease in the inflow flow through the virus removal filter. In some examples, the valve assembly circulates fluid from the virus removal filter outlet to the virus removal filter inlet. At the same time, the valve arrangement is configured to prevent viruses in the liquid flowing to the entrance of the virus removal filter from diffusing into the starting liquid. In some examples, the valve assembly automatically provides a recirculation buffer upon completion of the inflow flow reduction and resumption of full inflow flow to facilitate the escape of fluid trapped in the recirculation line.
    Figure 1 shows an example of a system 100 for reducing the migration of one or more viruses over and through a virus removal filter 110 when the inflow flow is resumed after the inflow flow has been reduced by the virus removal filter 110. Virus removal filter 110 includes a virus filtration membrane that is generally configured to size exclude virus from a product 126 (e.g., a pharmaceutical drug in solution) when the product flows through it by ensuring that the fluid flow through the virus filter 110 is continuous, so that viruses are not displaced and passed through the membrane of the virus filter 110, but are continuously and consistently enclosed in the membrane of the virus filter 110. Virus filter 110 is preferably made from regenerated celluloid, e.g. from Asahi KASEI Medical Co. LTD, although virus filter 110 can instead be made from polysulfone or polyvinylidene fluoride.
    In the illustrated example, system 100 takes the form of a valve assembly that includes an inlet line 102 that can be connected to filter 110, an outlet line 112 that can be connected to filter 110, and a pump 124 that inlet line 102, and includes a recirculation system 132 coupled to both inlet line 102 and outlet line 112 and configured to provide the continuous fluid flow described above. However, in other examples, system 100 may include different, additional, or fewer components. In particular, inlet conduit 102 includes an inlet opening 104 and an outlet opening 108. Inlet opening 104 is generally coupled to a supply 127 of product 126, which is used for virus removal to be passed through the filter 110. The supply and supply 127 of the product 126 can, for example, be or take the form of a tank or container which is suitable for receiving the product 126. In some cases, the feeder 127 may also receive or hold a buffer solution that helps pass the product 126 through the virus removal filter 110. In the meantime, the outlet opening 108 of the inlet line 102 is arranged such that it is connected to an inlet 109 of the filter 110. Thus, when the inlet line 102 is connected to the filter 110, the product 126 (and in some cases the buffer solution for conveying the product 126) flows from the feed 127 and to and through the filter 110 via the inlet opening 104 and the outlet opening 108 of the inlet line 102. The virus filtration membrane of filter 110 in turn captures all viruses contained in product 126 that flow from supply 127.
    [0011] The outlet line 112 is arranged such that it is coupled to an outlet 111 of the filter 110 via an inlet opening 114 of the outlet line 112. When outlet line 112 is coupled to filter 110, outlet line 112 sucks the filtered product 126 (i.e., the filtrate) that has passed through filter 110. Outlet line 112 may optionally be connected to other devices, e.g. processing means, to further process the product 126 or to facilitate the separation of the product 126 from the buffer solution (if used). In the example shown, the recirculation system 132 includes a recirculation line 130, which is arranged between the inlet and outlet lines 102, 112 and a check valve 122 along the recirculation line 130. In particular, the recirculation line 130 includes an inlet opening 134 and an outlet opening 136. The inlet opening 134 fluidly connects the recirculation line 130 to the inlet line 102 and the outlet opening 136 fluidly connects the recirculation line 130 to the outlet line 112. The check valve 122, on the other hand, is along the recirculation line 130 between the Inlet opening 134 and outlet opening 136 arranged, however
    CH 714 987 A2 at a position closer to the inlet opening 134 than to the outlet opening 136 (at least in this example). The check valve 122 in this example is a highly integrated, highly sensitive back pressure regulator manufactured by Equilibar, for example. Check valve 122 has a preset, closed position in which check valve 122 prevents fluid flow in both directions between inlet port 134 and outlet port 136 of recirculation line 130, and an open position in which check valve 122 prevents fluid flow in a direction A. from the outlet opening 136 to the inlet opening 134, but not in a direction B from the inlet opening 134 to the outlet opening 136. Thus, the check valve 122 ensures that no product 126 can flow into the outlet line 112 without first passing through the filter 110, regardless of its position. At the same time, the check valve 122 is also configured to detect a reduction in the inlet flow in the inlet line 102 (ie from the inlet opening 104 of the inlet line 102 to the outlet opening 108 of the inlet line 102) and to switch between the closed and the open position, depending on whether such a reduction is found.
    During normal operation of the system 100, the check valve 122 is in its closed position and the product 126 is passed into and through the filter 110. In particular, the pump 124 draws the product 126 from the supply 127 of the product 126 and guides the product 126 to and through the outlet opening 108 of the inlet line 102 and into the filter 110. Once in the filter 110, the product 126 passes through the virus filter membrane of the filter 110 (not shown). As explained above, the membrane of the filter 110 has a lattice structure that consists of various interconnected cavities and capillaries with diameters smaller than the cross section of the virus that is to be removed from the product 126. The diameter of the cavities and capillaries of the filter membrane can be, for example are between fifteen (15) and seventy-five (75) nanometers ("nm"). This grid structure forms a tortuous path for the flow of product 126 that captures the virus contained in product 126 to be removed. After passing through the filter membrane, the product 126 then leaves the filter 110 through the filter outlet 111 and enters the outlet line 112 via an inlet opening 114. The product 126 can be sucked out of the system 100 within the outlet line 112.
    [0014] In the course of normal operation, the inflow through the inlet line 102 can be reduced. In particular, the inflow from the inlet opening 104 to the outlet opening 108 of the inlet line 102 can be reduced (and in some cases completely interrupted). The reduction can be done for various reasons. For example, the buffer solution used to pass product 126 through filter 110 may be used up before all of product 126 is filtered through filter 110, inlet port 104 may be blocked, thereby causing flow through inlet line 102 is prevented, or a person may accidentally step on a portion of the inlet conduit 102, resulting in clogging. In any event, in the event that such a decrease in flow occurs, the present disclosure provides opportunities for reducing virus migration by resuming inflow after the previous reduction in inflow.
    When the inflow flow through the inlet line 102 (and thus the filter 110) is reduced, the system 100 responds in such a way that the virus migration through the virus removal filter 110 is reduced. As explained above, the check valve 122 is arranged such that it detects a reduction in the inflow through the inlet line 102. When check valve 122 detects a reduction in flow (e.g., by pulling pump 124 on check valve 122), check valve 122 moves from its closed position to its open position. This in turn allows the fluid to flow in the direction A from the outlet opening 136 to the inlet opening 134 and creates a recirculation circuit in the system 100, i.e. from the inlet line 102 through the filter 110, the filter 110 to the outlet line 112, the outlet line 112 to the recirculation line 130 and the recirculation line 130 back to the inlet line 102. The creation of this recirculation circuit enables the pump 124 to continuously feed the product 126 through the outlet opening 108 of the Recirculate inlet conduit 102 and filter 110 so that the fluid continues to flow to and through filter 110 while reducing the inflow, thereby reducing virus mobility by ensuring that a virus trapped in the filter membrane of filter 110 during the reduction of the inflow remains immobilized. In some cases, e.g. when the inflow flow through inlet line 102 is completely interrupted, pump 124 continuously recirculates substantially all of the product 126 that is in or has passed through inlet line 102 and has not yet been removed from the system via outlet line 112. In other cases, e.g. if the inflow flow is only partially reduced, the pump 124 recirculates at least a portion of the product 126 that is in or has passed through the inlet 102, which portion is equal to the amount of reduction in the inflow flow. For example, if there is a 50% reduction in the inflow flow, the pump 124 recirculates about 50% of the product 126 that is in or has passed through the inlet 102, while the remaining about 50% is sucked out of the system 100 so that total fluid flowing through inlet 102 is approximately equal to the amount flowing through it prior to reduction.
    The system 100 continues to recirculate the fluid in this way until the reduction in flow is complete and the full inflow and inflow is resumed. As soon as the check valve 122 detects that the full inflow has been resumed, the check valve 122 moves from its open position to its closed position, so that the fluid no longer flows from the outlet line 112 to the inlet line 102 via the recirculation line 130 and thus the recirculation circuit can close.
    Fig. 2 shows an example of a system 200 for reducing the migration of one or more viruses over and through the virus removal filter 110 when the full inflow is resumed after a reduction in the inflow
    CH 714 987 A2. The system 200 shown in FIG. 2 is similar to the system 100 shown in FIG. 1, with common components that are shown with common reference numerals, but differs in that the system 200 includes a recirculation system 232 that is different from the recirculation system 132 of FIG Systems 100 makes a difference. In this example, the recirculation system 232 includes the check valve 122, but also a shut-off valve 216 and a rupture disk 218, which are each arranged on the recirculation line 130.
    The shut-off valve 216 is arranged along the recirculation line 130 between the inlet opening 134 and the outlet opening 136, but at a position which is closer to and adjacent to the outlet opening 136 (at least in this example). The shut-off valve 216 has an open position in which the valve 216 allows fluid flow between the inlet opening 134 and the outlet opening 136 and a closed position in which the valve 116 prevents fluid flow between the inlet opening 134 and the outlet opening 136. In other words, when the shutoff valve 216 is in the closed position, the shutoff valve 216 redundantly prevents any fluid flow from the inlet port 134 of the recirculation line 130 to the outlet port 136 of the recirculation line 130 in the event that the check valve 122 fails or the product 126 is somehow through the check valve 122 should tile. In the meantime, the rupture disk 218 is also arranged along the recirculation line 130 between the inlet opening 134 and the outlet opening 136, but at a location between the check valve 122 and the shut-off valve 216. The rupture disk 218 has a membrane which seals the recirculation line 130, but at one predetermined differential pressure fails, so that the fluid can flow freely at this time.
    During normal operation of system 200, check valve 122 is closed, shut-off valve 216 is open (although it can be closed instead), and product 126 flows through inlet conduit 102, through filter 110, and out of system 200 outlet conduit 112 in a manner similar to that described above in connection with system 100. Furthermore, since the check valve 122 is closed, there is a uniform pressure differential (or a substantially uniform pressure differential) across the rupture disc 218 so that the forces on both sides of the rupture disc 218 are equal. This uniform pressure difference across the rupture disc 218 ensures that the rupture disc 218 remains intact and seals the recirculation line 130.
    However, if a reduction in the inflow in the inlet line 102 (and thus the filter 110) occurs during the normal operation of the system 200, the system 200 responds in such a way that the potential for virus migration through the virus removal filter 110 is reduced. When the check valve 122 detects a reduction in the flow rate, the check valve 122 moves from its closed position to its open position and the shut-off valve 216 is moved from its closed position to its open position (if it was closed), e.g. in response to instructions from check valve 122 or instructions from a controller (not shown). This in turn enables the pump 124 to exert a vacuum on the rupture disc 218, i.e. expose the rupture disc 218 to an uneven pressure differential. The non-uniform pressure difference creates a force on one side of the rupture disk 218 that is greater than the force exerted on the other side of the rupture disk 218. This uneven distribution of forces causes the rupture disc 218 to rupture (i.e., permanently open).
    If the rupture disc 218 bursts and as long as the check valve 122 and the shut-off valve 216 are in their open positions, it should be noted that the fluid has an unobstructed path from the outlet port 136 to the inlet port 134 that allows the fluid from which Exhaust line 112 to flow to inlet 102 through recirculation line 130. This creates a recirculation cycle in system 200, i.e. from the input line 102 through the filter 110, the filter 110 to the output line 112, the output line 112 to the recirculation line 130 and the recirculation line 130 back to the input line 102. The formation of this recirculation circuit enables the pump 124 to continuously pass the product 126 through the outlet opening 108 of the Recirculate inlet line 102 and filter 110 during flow reduction so that the fluid flows continuously to and through filter 110 during flow reduction, thereby reducing virus mobility by ensuring that a virus trapped in the filter membrane of filter 110 is reduced during flow reduction remains immobilized. In some cases, e.g. when the flow is completely interrupted, the pump 124 continuously recirculates substantially all of the product 126 that is in or has passed through the inlet line 102 and has not yet been removed from the system via the outlet line 112. In other cases, e.g. if the flow rate is only partially reduced, the pump 124 recirculates at least a portion of the product 126 that is in or has passed through the inlet 102, which portion is equal to the amount of liquid reduction. For example, if there is a 50% reduction in flow, the pump 124 recirculates about 50% of the product 126 that is in or has passed through the inlet 102, while the remaining about 50% is sucked out of the system 100 so that the total amount of fluid flowing through inlet 102 is approximately equal to the amount flowing through it prior to reduction.
    The system 200 recirculates the product 126 until the reduction is complete and the full inflow is resumed. Once check valve 122 detects that full flow has resumed, check valve 122 moves from its open position to its closed position, and system 200 causes check valve 216 to transition from its open position to its closed position so that the fluid can no longer flow from the output line 112 to the input line 102 via the recirculation line 130, as a result of which the recirculation circuit is closed. In other words, the outlet line 112 is fluidly separated from the inlet line 102.
    CH 714 987 A2 [0023] As soon as the shut-off valve 216 has returned to the closed position and the inflow is no longer reduced, the rupture disc 218 within the recirculation system 232 must of course be replaced. For example, a person may be required to manually remove the rupture disc 218 used and replace it with a new rupture disc 218. In another example, however, the replacement of the rupture disc 218 can be automated. The automation of the exchange acts as redundancy if a person forgets to replace the disc and helps to create a more autonomous system 200.
    FIG. 3 shows an example of a system 300 for reducing the migration of one or more viruses over and through the virus removal filter 110 when the inflow flow is resumed after the inflow flow has been reduced by the virus removal filter 110. System 300 shown in FIG. 3 is constructed similarly to system 200 shown in FIG. 2, with common components that are provided with common reference numerals, but differs in that system 300 includes a recirculation system 332 that is different from the recirculation system 232 of the system 200 differs. In particular, the recirculation system 332 in this example includes the check valve 122, the shut-off valve 216 and the rupture disk 218, but also a second shut-off valve 317, a third shut-off valve 319 and a source 320 of the recirculation buffer solution 321 (i.e. a second buffer solution).
    As shown in FIG. 3, the second shut-off valve 317 is arranged along the inlet line 102 at a location between the pump 124 and the inlet opening 104. In particular, the second shut-off valve 317 is arranged along the inlet line 102 between the inlet opening 134 of the recirculation line 130 and the inlet opening. Like the shutoff valve 216, the second shutoff valve 317 has an open and a closed position. However, when the shutoff valve 317 is in its open position, the valve 317 allows fluid flow between the inlet port 104 and the inlet port 134. Thus, when the shutoff valve 317 is in its open position, the valve 317 allows the product 126 to flow from the source 127 to the pump 124. Conversely, when the shut-off valve 317 is in its closed position, the valve 317 prevents fluid flow between the inlet port 104 and the inlet port 134 so that no product 126 can flow to the pump 124 (i.e. the inflow flow is zero).
    The third shut-off valve 319 and the source 320 of the recirculation buffer solution 321 are fluidly connected to the recirculation line 130. In the example shown, the third shut-off valve 319 and the source 320 are each arranged along a recirculation line 331 which is connected to the recirculation line 130 between the check valve 122 and the rupture disk 218. When the recirculation line 331 is thus connected to the recirculation line 130, the third shut-off valve 319 is arranged between the recirculation line 130 and the source 320 of the recirculation buffer solution 321. Like the shutoff valve 317, the third shutoff valve 319 has an open and a closed position. However, when the shutoff valve 319 is in its open position, the valve 319 allows fluid flow between the source 320 and the recirculation line 130. When the shutoff valve 319 is in its open position, the valve 319 thus releases the recirculation buffer solution 321 from the source 320 flow to recirculation line 130. Conversely, when the shutoff valve 319 is in its closed position, the valve 319 prevents fluid flow between the source 320 and the recirculation line 130.
    The system 300 works similarly to the system 200 in normal operation and reacts to a reduction in the flow rate in the inlet line 102 (and thus the filter 110). In particular, during normal operation of system 300, check valve 122 is closed, first shutoff valve 216 is open (although it may alternatively be closed), second shutoff valve 317 is open, and third shutoff valve 319 is closed, so that product 126 through input line 102, flows through the filter 110 and out of the system 200 via the output line 112. And when the check valve 122 detects an admission flow reduction in the inlet line 102, the check valve 122 moves from its closed position to its open position and the first shut-off valve 216 is moved from its closed position to its open position (if it was closed), thereby causing a Recirculation cycle in system 300 is established as described above in connection with system 200.
    However, as soon as the reduction of the inflow flow has ended and the full inflow flow is resumed, the system 300 is configured so that it automatically (ie without human intervention) all liquids enclosed in the return line or recirculation line 130 from the recirculation line 130 and out can flow out of the system 300. In particular, once check valve 122 detects that full flow has resumed, check valve 122 moves from its open position to its closed position, and system 200 causes first shutoff valve 216 to transition from its open position to its closed position , the second shut-off valve 317 changes from its open position to its closed position and the third shut-off valve 319 changes from its closed position to its open position. While the inlet line 102 is fluidly isolated from the outlet line 112, the recirculation buffer solution 321 flows from the source 320 to and through the third shut-off valve 319, via the recirculation branch line 331 and to and through the check valve 122 via the recirculation line 130. The recirculation buffer solution 321 checks everyone Liquids that would otherwise be trapped in recirculation line 130 when check valve 122 detects that full flow has resumed. This enclosed liquid then flows through the inlet line 102 to and through the virus removal filter 110 and is led out of the system 300 via the outlet line 112.
    CH 714 987 A2 It should be noted that the components of system 100, system 200 and system 300 may be made from one or more different materials. Preferably, the components of system 100, system 200 and system 300, e.g. the inlet line 102, the outlet line 112 and the recirculation line 130, each in the form of a line made of a single-use material such as a plastic material such as gamma-stable plastic (which can withstand gamma radiation). However, in some examples, inlet line 102, outlet line 112, recirculation line 130, and / or other components may instead be made of a metallic material (e.g., stainless steel).
    Those skilled in the art will recognize that a variety of modifications, changes, and combinations can be made with respect to the above-described embodiments without departing from the scope of the disclosure, and that such modifications, changes, and combinations are considered to be within the scope of the inventive concept are to be seen.
    权利要求:
    Claims (23)
    [1]
    claims
    1. A valve arrangement for reducing the migration of one or more viruses through a virus removal filter when the inflow flow to the virus removal filter is resumed after the inflow flow has been reduced, the valve arrangement comprising:
    an inlet conduit with an inlet opening and an outlet opening, the inlet opening being suitable for being connected to an inflow of a product which is to be passed through a virus removal filter which filters viruses from the product and the outlet opening is suitable for having an inlet of the Virus removal filter to be connected;
    a pump arranged on the inlet line between the inlet opening and the outlet opening to convey the product into the inlet of the filter;
    an outlet conduit with an inlet opening which can be connected to an outlet of the filter in order to suck the filtered product out of the filter;
    a recirculation system arranged to continuously return fluid through the valve assembly when the inflow flow from the inlet line of the inlet line to the outlet opening of the inlet line is reduced, the recirculation system comprising:
    a recirculation line having an inlet opening connected to the inlet line and an outlet opening connected to the outlet line; and a check valve disposed along the recirculation line between the inlet opening of the recirculation line and the outlet opening of the recirculation line, the check valve being configured to sense that the inlet flow has been reduced;
    wherein when the check valve detects that the inflow has been reduced, the check valve moves from a closed position in which the check valve prevents fluid flow between the inlet and outlet openings of the recirculation line to an open position in which the check valve prevents the fluid flow from enables the recirculation line outlet port to the recirculation line inlet port, thereby creating a recirculation circuit that includes the inlet line through the filter, the filter to the outlet line, the outlet line to the recirculation line, and the recirculation line to the inlet line, so that the product continuously during the reduction of the inflow is returned through the filter.
    [2]
    2. Valve arrangement according to claim 1, wherein when the check valve detects that the flow reduction has stopped, the check valve changes from the open position to the closed position and thereby closes the recirculation circuit.
    [3]
    3. The valve assembly of claim 1, wherein the recirculation system further comprises a first shutoff valve disposed along the recirculation line, the shutoff valve having an open position in which the first shutoff valve allows fluid flow between the inlet and outlet ports of the recirculation line, and one closed position in which the first shut-off valve prevents fluid flow between the inlet and outlet openings of the recirculation line.
    [4]
    4. The valve assembly of claim 3, wherein when the check valve determines that the flow has been reduced, the first shut-off valve changes from the closed position to the open position.
    [5]
    5. The valve assembly of claim 3, wherein the recirculation system further comprises a rupture disc disposed along the recirculation line between the outlet of the recirculation line and the first shutoff valve, and when the first shutoff valve is in the open position and the check valve in the open position, the pump causes the rupture disc to rupture.
    [6]
    6. The valve assembly of claim 5, wherein the recirculation system further comprises a supply of a recirculation buffer solution that is fluidly connected to the recirculation line between the check valve and the first shut-off valve.
    CH 714 987 A2
    [7]
    7. The valve assembly of claim 6, wherein the recirculation system further comprises a second shutoff valve disposed along the inlet line between the pump and the inflow of the product to selectively fluidly connect the inflow of the product to the pump.
    [8]
    8. The valve assembly of claim 7, wherein the recirculation system further comprises a third shutoff valve disposed between the check valve and the supply of recirculation buffer solution to selectively fluidly connect the inflow of recirculation buffer solution to the recirculation line.
    [9]
    9. The valve assembly of claim 1, wherein the inlet line, the outlet line, the pump, the recirculation line, and the check valve are each made of a disposable material.
    [10]
    10. The valve assembly of claim 9, wherein the disposable material comprises a gamma stable plastic material.
    [11]
    11. A valve arrangement for reducing the migration of one or more viruses through a virus removal filter when the inflow flow to the virus removal filter is resumed after the inflow flow has been reduced, the valve arrangement comprising:
    an inlet conduit with an inlet opening and an outlet opening, the inlet opening being suitable for being connected to an inflow of a product which is to be passed through a virus removal filter which filters viruses from the product and the outlet opening is suitable for having an inlet of the Virus removal filter to be connected;
    a pump arranged on the inlet line between the inlet opening and the outlet opening to convey the product into the inlet of the filter;
    an outlet conduit with an inlet opening which can be connected to an outlet of the filter in order to suck the filtered product out of the filter;
    a recirculation system arranged to continuously return fluid through the valve assembly when the inflow flow from the inlet line of the inlet line to the outlet opening of the inlet line is reduced, the recirculation system comprising:
    a recirculation line having an inlet opening connected to the inlet line and an outlet opening connected to the outlet line; and a check valve disposed along the recirculation line between the inlet opening of the recirculation line and the outlet opening of the recirculation line, the check valve configured to sense that the inflow flow has been reduced;
    wherein when the check valve detects that the inflow has been reduced, the check valve moves from a closed position in which the check valve prevents fluid flow between the inlet and outlet openings of the recirculation line to an open position in which the check valve prevents the fluid flow from the outlet of the recirculation line to the inlet of the recirculation line, thereby creating a recirculation circuit that includes the inlet line through the filter, the filter to the outlet line, the outlet line to the recirculation line, and the recirculation line to the inlet line, so that the product continuously during the reduction of the inflow is returned through the filter, and when the check valve detects that the flow reduction has stopped, the check valve moves from the open position to the closed position and thereby the recirculation onskreislauf closes, and wherein the inlet line, the outlet line, the pump, the recirculation line and the check valve are each made of a disposable material.
    [12]
    12. The valve assembly of claim 11, wherein the recirculation system further includes a first shutoff valve disposed along the recirculation line, the shutoff valve having an open position in which the first shutoff valve allows fluid flow between the inlet and outlet ports of the recirculation line, and one closed position in which the first shut-off valve prevents fluid flow between the inlet and outlet openings of the recirculation line.
    [13]
    13. The valve assembly of claim 12, wherein when the check valve determines that the inflow flow has been reduced, the first shut-off valve changes from the closed position to the open position.
    [14]
    14. The valve assembly of claim 12, wherein the recirculation system further comprises a rupture disc disposed along the recirculation line between the outlet of the recirculation line and the first shutoff valve, and wherein when the first shutoff valve is in the open position and the check valve is in the open position Position, the pump causes the rupture disc to rupture.
    [15]
    15. The valve assembly of claim 14, wherein the recirculation system further comprises a supply of recirculation buffer solution that is fluidly connected to the recirculation line between the check valve and the first shut-off valve.
    [16]
    16. The valve assembly of claim 15, wherein the recirculation system further comprises:
    a second shut-off valve disposed along the inlet line between the pump and the inflow of the product to selectively fluidly connect the inflow of the product to the pump; and
    CH 714 987 A2, a third shut-off valve, which is arranged between the check valve and the supply of recirculation buffer solution in order to selectively fluidly connect the supply of recirculation buffer solution to the recirculation line.
    [17]
    17. A method of reducing the migration of one or more viruses through a virus removal filter when the inflow to the virus removal filter is resumed after the inflow flow has been reduced, the method comprising:
    Providing an inlet conduit with an inlet opening and an outlet opening; Providing an outlet conduit with an inlet opening;
    Connecting the inlet opening to a supply of a product to be passed through the virus removal filter, connecting the outlet opening to an inlet of a virus removal filter that filters viruses from the product, and connecting the inlet opening of the outlet line to an outlet of the filter in order to discharge the filtered product remove the filter;
    Providing a recirculation system comprising a recirculation line and a check valve arranged along the recirculation line, the recirculation line having an inlet opening and an outlet opening;
    Connecting the inlet opening of the recirculation line to the inlet line and the outlet opening of the recirculation line to the outlet line;
    Simplifying the flow of the product from the inflow of the product to the outlet opening of the inlet line via a pump which is arranged on the inlet line between the inlet opening and the outlet opening of the inlet line;
    Detecting a reduction in inflow flow through the check valve; and
    Generating a recirculation circuit in response to detecting the reduction, which recirculation circuit is formed through the inlet line through the filter, the filter to the outlet line, the outlet line to the recirculation line, and the recirculation line to the inlet line, so that the product continues to flow through the inlet during the reduction Filter is returned.
    [18]
    18. The method of claim 17, wherein generating the recirculation circuit comprises moving the check valve from a closed position, in which the check valve prevents fluid flow between the inlet and outlet openings of the recirculation line, to an open position, in which the check valve prevents the fluid flow from allows the outlet opening of the recirculation line to the inlet opening of the recirculation line.
    [19]
    19. The method of claim 17, wherein providing the recirculation system further comprises providing a first shut-off valve disposed along the recirculation line, the shut-off valve having an open position in which the first shut-off valve provides fluid flow between the inlet and outlet ports of the recirculation line and a closed position in which the first shut-off valve prevents fluid flow between the inlet and outlet openings of the recirculation line.
    [20]
    20. The method of claim 19, wherein in response to sensing the reduction, the first shutoff valve is moved from the closed position to the open position.
    [21]
    21. The method of claim 19, wherein providing the recirculation system further comprises providing a rupture disk disposed along the recirculation line between the outlet opening of the recirculation line and the first shutoff valve.
    [22]
    22. The method of claim 19, wherein providing the recirculation system further comprises providing a supply of recirculation buffer solution that is fluidly connected to the recirculation line between the check valve and the first shutoff valve.
    [23]
    23. The method of claim 19, wherein providing the recirculation system further comprises:
    Providing a second shut-off valve located along the inlet line between the pump and the supply of the product to selectively fluidly connect the supply of the product to the pump; and providing a third shutoff valve disposed between the check valve and the supply of recirculation buffer solution to selectively fluidly connect the supply of recirculation buffer solution to the recirculation line.
    CH 714 987 A2

    CH 714 987 A2
    300
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    同族专利:
    公开号 | 公开日
    US20190336915A1|2019-11-07|
    BR102019008780A2|2019-12-10|
    AR114849A1|2020-10-21|
    US10618007B2|2020-04-14|
    RU2019113116A|2020-11-02|
    CN110420562A|2019-11-08|
    EP3563876A1|2019-11-06|
    CA3041321A1|2019-11-01|
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    法律状态:
    2021-12-15| AZW| Rejection (application)|
    优先权:
    申请号 | 申请日 | 专利标题
    US15/968,445|US10618007B2|2018-05-01|2018-05-01|Systems and methods of reducing virus migration through a virus removal filter after feed flow reduction|
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